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. 2020 May 4;18:47. doi: 10.1186/s12915-020-00779-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Examples of CHi-C Interactions implicating nearest/reported genes. Interactions are shown in the 9q31.2 (KLF4) locus (a) and the 5p13.1 (PTGER4) locus (b). The tracks include psoriasis (Ps) LD blocks as defined by SNPs in r² > 0.8 with the index SNP, baited HindIII fragments, RefSeq genes (NCBI), H3K27ac and H3K4me3 P value signal in NHEK (ENCODE) and CD8+ primary naive T cells (Roadmap Epigenomics), TADs (shown as bars) and CHi-C interactions significant at CHiCAGO score ≥ 5 (shown as arcs) in three conditions: unstimulated HaCat cells (purple), HaCaT cells stimulated with IFN-γ (red) and My-La cells (blue). The highlighted region indicates the psoriasis LD block. The figure was made with the WashU Epigenome Browser, GRCh37/hg19 [31]