Table 2.

Experiment 2: Comparison of immune cell densities in eyes with different topical treatments after 6 h (i.e., 3× doses, 2 h apart)

	Main effects						Interactions
	Decorin		Fluid gel		Contralateral eye effect		Decorin # Gel	Gel # Contralateral
	Contrast (95% CI)	p value	Contrast (95% CI)	p value	Contrast (95% CI)	p value	p value	p value
Re-epithelialisation (%)	2.4 (− 3.1, 8.0)	0.377	− 3.9 (− 9.9, 2.1)	0.192	0.1 (− 5.5, 5.7)	0.977	0.982	0.878
Stromal thickness (μm)	− 0.8 (− 9.8, 8.1)	0.854	16.5 (7.1, 26.0)	0.002	2.5 (− 6.4, 11.3)	0.573	0.204	0.153
Peripheral cornea
DCs (cells/mm2)	15.7 (7.6, 23.8)	< 0.001	− 4.6 (− 13.0, 3.7)	0.261	3.4 (− 4.7, 11.5)	0.400	0.200	0.248
DC area (μm2/cell)	119.3 (− 68.8, 307.4)	0.205	− 172.6 (− 369.7, 24.5)	0.083	137.1 (− 51.0, 325.2)	0.147	0.460	0.302
Macrophages (cells/mm2)	− 6.9 (− 23.4, 9.5)	0.396	− 0.2 (− 18.0, 17.5)	0.977	− 10.4 (− 26.9, 6.1)	0.206	0.196	0.832
Neutrophils (cells/mm2)	− 144.5 (− 343.9, 54.9)	0.150	− 135.4 (− 342.3, 71.5)	0.188	− 281.1 (− 480.5, − 81.8)	0.007	0.071	0.317

Statistics are derived from mixed-effects models. Data are also shown in Fig. 4 and Supplemental file Fig. S4. P value indicates the significance of the contrast between the eyes with or without the intervened effect (decorin, fluid gel and etc.)

CI confidence interval, DC dendritic cell