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. 2020 May 4;18:36. doi: 10.1186/s12958-020-00601-3

Table 3.

Univariate and multivariate logistic regression model about NC, HRT and OI protocols

Crude OR (95% Cl) P-value Adjusted OR (95% Cl) P-value
HDP
 NC 1 1
 HRT 2.36 (1.86–2.99) < 0.001* 2.00 (1.54–2.60) < 0.001*
 OI 1.34 (0.86–2.07) 0.193 1.02 (0.62–1.65) 0.853
GDM
 NC 1 1
 HRT 1.25 (0.99–1.58) 0.061 1.10 (0.84–1.45) 0.470
 OI 1.48 (1.04–2.10) 0.028* 1.49 (0.97–2.19) 0.056
Placenta previa
 NC 1 1
 HRT 1.48 (0.90–2.42) 0.122 1.52 (0.88–2.64) 0.133
 OI 1.17 (0.50–2.75) 0.720 1.35 (0.55–3.27) 0.514
Oligohydramnios
 NC 1 1
 HRT 0.80 (0.47–1.37) 0.419 0.70 (0.40–1.24) 0.225
 OI 1.36 (0.67–2.75) 0.399 1.06 (0.49–2.29) 0.887
PTB
 NC 1 1
 HRT 1.84 (1.47–2.30) < 0.001* 1.78 (1.39–2.28) < 0.001*
 OI 1.76 (1.24–2.50) 0.002* 1.51 (1.02–2.23) 0.041*
LBW
 NC 1 1
 HRT 1.67 (1.25–2.23) 0.001* 1.49 (1.09–2.06) 0.014*
 OI 1.35 (0.83–2.20) 0.231 1.17 (0.70–1.96) 0.547
SGA
 NC 1 1
 HRT 0.83 (0.60–1.15) 0.271 0.85 (0.60–1.21) 0.370
 OI 1.46 (0.96–2.24) 0.078 1.47 (0.94–2.31) 0.092
LGA
 NC 1 1
 HRT 1.16 (1.02–1.33) 0.021* 1.15 (0.99–1.33) 0.058
 OI 0.93 (0.75–1.16) 0.505 0.98 (0.77–1.24) 0.842

NC natural cycle, HRT hormone replacement therapy, OI ovulation induction, OR odds ratio, CI confidence interval, HDP hypertensive disorders of pregnancy, GDM gestational diabetes mellitus, PTB preterm birth, LBW low birth weight, SGA small for gestational age, LGA large for gestational age

Adjustment included age, body mass index, irregular menstruation, donor sperm using, FET cycle number, number of transferred embryos, vanishing twin gestation, preconceptional fasting glucose, systolic pressure, diastolic pressure, endometrial thickness, antral follicle count, testosterone level, anti-Müllerian hormone

*There were significant differences between groups