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. 2020 May 4;2020(5):CD012955. doi: 10.1002/14651858.CD012955.pub2

Comparison 1. Psychotherapy vs TAU.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1.1 Primary: BPD symptom severity (continuous) 23   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
1.1.1 End of treatment 22 1244 Std. Mean Difference (IV, Random, 95% CI) ‐0.52 [‐0.70, ‐0.33]
1.1.2 0‐6 months follow‐up 2 41 Std. Mean Difference (IV, Random, 95% CI) ‐0.59 [‐1.23, 0.05]
1.1.3 6‐12 months follow‐up 2 157 Std. Mean Difference (IV, Random, 95% CI) ‐0.04 [‐0.36, 0.27]
1.1.4 12 months and over follow‐up 2 97 Std. Mean Difference (IV, Random, 95% CI) ‐0.94 [‐2.58, 0.70]
1.2 Primary: BPD symptom severity (dichotomous), at above 12 months follow‐up 1   Risk Ratio (IV, Fixed, 95% CI) Subtotals only
1.3 Primary: self‐harm (continuous) 13   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
1.3.1 End of treatment 13 616 Std. Mean Difference (IV, Random, 95% CI) ‐0.32 [‐0.49, ‐0.14]
1.3.2 0‐6 months follow‐up 1 28 Std. Mean Difference (IV, Random, 95% CI) ‐0.52 [‐1.28, 0.23]
1.3.3 6‐12 months follow‐up 3 174 Std. Mean Difference (IV, Random, 95% CI) ‐0.18 [‐0.48, 0.12]
1.4 Primary: self‐harm (dichotomous) 6   Risk Ratio (IV, Random, 95% CI) Subtotals only
1.4.1 End of treatment 6 513 Risk Ratio (IV, Random, 95% CI) 0.85 [0.63, 1.14]
1.4.2 0‐6 months follow‐up 1 41 Risk Ratio (IV, Random, 95% CI) 0.14 [0.04, 0.56]
1.4.3 6‐12 months follow‐up 1 41 Risk Ratio (IV, Random, 95% CI) 0.27 [0.10, 0.68]
1.4.4 12 months and over follow‐up 1 41 Risk Ratio (IV, Random, 95% CI) 0.33 [0.15, 0.76]
1.5 Primary: suicide‐related outcomes (continuous) 13   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
1.5.1 End of treatment 13 666 Std. Mean Difference (IV, Random, 95% CI) ‐0.34 [‐0.57, ‐0.11]
1.5.2 0‐6 months follow‐up 2 36 Std. Mean Difference (IV, Random, 95% CI) ‐0.43 [‐1.10, 0.23]
1.5.3 6‐12 months follow‐up 2 109 Std. Mean Difference (IV, Random, 95% CI) ‐0.42 [‐0.80, ‐0.04]
1.5.4 Above 12 months follow‐up 1 76 Std. Mean Difference (IV, Random, 95% CI) ‐0.31 [‐0.77, 0.14]
1.6 Primary: suicide‐related outcomes (dichotomous) 5   Risk Ratio (IV, Random, 95% CI) Subtotals only
1.6.1 End of treatment 5 396 Risk Ratio (IV, Random, 95% CI) 0.27 [0.11, 0.67]
1.6.2 0‐6 months follow‐up 1 41 Risk Ratio (IV, Random, 95% CI) 0.25 [0.06, 1.05]
1.6.3 Above 12 months follow‐up 1 41 Risk Ratio (IV, Random, 95% CI) 0.29 [0.11, 0.74]
1.7 Primary: psychosocial functioning (continuous) 23   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
1.7.1 End of treatment 22 1314 Std. Mean Difference (IV, Random, 95% CI) ‐0.45 [‐0.68, ‐0.22]
1.7.2 0‐6 months follow‐up 1 9 Std. Mean Difference (IV, Random, 95% CI) ‐1.23 [‐2.74, 0.29]
1.7.3 6‐12 months follow‐up 3 247 Std. Mean Difference (IV, Random, 95% CI) ‐0.09 [‐0.40, 0.23]
1.7.4 Above 12 months follow‐up 6 499 Std. Mean Difference (IV, Random, 95% CI) ‐0.27 [‐0.60, 0.05]
1.8 Secondary: anger (continuous) 8   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
1.8.1 End of treatment 8 323 Std. Mean Difference (IV, Random, 95% CI) ‐0.38 [‐0.64, ‐0.12]
1.8.2 0‐6 months follow‐up 1 8 Std. Mean Difference (IV, Random, 95% CI) ‐1.20 [‐2.82, 0.41]
1.8.3 6‐12 months follow‐up 2 111 Std. Mean Difference (IV, Random, 95% CI) ‐0.12 [‐0.50, 0.25]
1.8.4 Above 12 months follow‐up 1 80 Std. Mean Difference (IV, Random, 95% CI) 0.02 [‐0.42, 0.46]
1.9 Secondary: affective instability (continuous) 12   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
1.9.1 End of treatment 12 620 Std. Mean Difference (IV, Random, 95% CI) ‐0.68 [‐0.98, ‐0.39]
1.9.2 6‐12 months follow‐up 1 33 Std. Mean Difference (IV, Random, 95% CI) ‐0.52 [‐1.21, 0.18]
1.10 Secondary: chronic feelings of emptiness (continuous) 4   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
1.10.1 End of treatment 4 187 Std. Mean Difference (IV, Random, 95% CI) ‐0.39 [‐0.69, ‐0.10]
1.10.2 6‐12 months follow‐up 1 33 Std. Mean Difference (IV, Random, 95% CI) ‐0.58 [‐1.28, 0.11]
1.11 Secondary: impulsivity (continuous) 10   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
1.11.1 End of treatment 10 491 Std. Mean Difference (IV, Random, 95% CI) ‐0.54 [‐0.84, ‐0.25]
1.11.2 6‐12 months follow‐up 2 77 Std. Mean Difference (IV, Random, 95% CI) 0.32 [‐0.13, 0.77]
1.12 Secondary: impulsivity (dichotomous), at end of treatment 1   Risk Ratio (IV, Fixed, 95% CI) Subtotals only
1.13 Secondary: interpersonal problems (continuous) 18   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
1.13.1 End of treatment 18 1159 Std. Mean Difference (IV, Random, 95% CI) ‐0.42 [‐0.68, ‐0.16]
1.13.2 0‐6 months follow‐up 1 53 Std. Mean Difference (IV, Random, 95% CI) ‐0.41 [‐1.01, 0.20]
1.13.3 6‐12 months follow‐up 2 132 Std. Mean Difference (IV, Random, 95% CI) ‐0.17 [‐0.65, 0.32]
1.13.4 Above 12 months follow‐up 3 172 Std. Mean Difference (IV, Random, 95% CI) 0.00 [‐0.54, 0.54]
1.14 Secondary: abandonment (continuous) 2   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
1.14.1 End of treatment 2 84 Std. Mean Difference (IV, Random, 95% CI) ‐0.22 [‐0.66, 0.21]
1.14.2 6‐12 months follow‐up 1 33 Std. Mean Difference (IV, Random, 95% CI) ‐0.39 [‐1.08, 0.30]
1.15 Secondary: identity disturbance (continuous) 4   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
1.15.1 End of treatment 4 250 Std. Mean Difference (IV, Random, 95% CI) ‐0.37 [‐0.84, 0.10]
1.15.2 6‐12 months follow‐up 1 33 Std. Mean Difference (IV, Random, 95% CI) ‐1.09 [‐1.83, ‐0.35]
1.16 Secondary: dissociation and psychotic‐like symptoms (continuous) 6   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
1.16.1 End of treatment 6 244 Std. Mean Difference (IV, Random, 95% CI) ‐0.47 [‐0.85, ‐0.10]
1.16.2 0‐6 months follow‐up 2 35 Std. Mean Difference (IV, Random, 95% CI) ‐0.97 [‐1.69, ‐0.26]
1.16.3 6‐12 months follow‐up 1 33 Std. Mean Difference (IV, Random, 95% CI) ‐0.59 [‐1.29, 0.11]
1.16.4 12 months and over follow‐up 1 24 Std. Mean Difference (IV, Random, 95% CI) ‐0.01 [‐0.81, 0.79]
1.17 Secondary: depression (continuous) 22   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
1.17.1 End of treatment 22 1568 Std. Mean Difference (IV, Random, 95% CI) ‐0.39 [‐0.61, ‐0.17]
1.17.2 0‐6 months follow‐up 4 125 Std. Mean Difference (IV, Random, 95% CI) ‐0.80 [‐1.26, ‐0.34]
1.17.3 6‐12 months follow‐up 3 260 Std. Mean Difference (IV, Random, 95% CI) ‐0.40 [‐0.95, 0.16]
1.17.4 12 months and over follow‐up 5 311 Std. Mean Difference (IV, Random, 95% CI) ‐0.40 [‐0.74, ‐0.06]
1.18 Secondary: depression (dichotomous), at end of treatment 1   Risk Ratio (IV, Fixed, 95% CI) Subtotals only
1.19 Secondary: attrition (dichotomous) 33   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
1.19.1 End of treatment 32 2225 Risk Ratio (M‐H, Random, 95% CI) 1.00 [0.83, 1.20]
1.19.2 0‐6 months follow‐up 1 60 Risk Ratio (M‐H, Random, 95% CI) 0.58 [0.34, 1.00]
1.20 Secondary: non‐serious adverse effects (dichotomous), at end of treatment 2 381 Risk Ratio (M‐H, Random, 95% CI) 0.92 [0.45, 1.88]
1.21 Secondary: serious adverse effects (dichotomous), at end of treatment 4 571 Risk Ratio (IV, Fixed, 95% CI) 0.86 [0.14, 5.09]