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. 2020 May 4;2020(5):CD012955. doi: 10.1002/14651858.CD012955.pub2

Comparison 5. Cognitive behavioural therapy (CBT) and related treatments vs TAU.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
5.1 Primary: BPD symptom severity (continuous) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
5.1.1 End of treatment 1 26 Mean Difference (IV, Fixed, 95% CI) ‐3.08 [‐4.99, ‐1.17]
5.1.2 0‐6 months follow‐up 1 26 Mean Difference (IV, Fixed, 95% CI) ‐2.02 [‐4.23, 0.19]
5.2 Primary: BPD symptom severity (dichotomous), at above 12 months follow‐up 1 76 Risk Ratio (IV, Fixed, 95% CI) 0.91 [0.56, 1.48]
5.3 Primary: self‐harm (continuous) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
5.3.1 End of treatment 1 28 Mean Difference (IV, Fixed, 95% CI) ‐3.03 [‐5.68, ‐0.38]
5.3.2 0‐6 months follow‐up 1 28 Mean Difference (IV, Fixed, 95% CI) ‐4.71 [‐11.60, 2.18]
5.4 Primary: self‐harm (dichotomous), at end of treatment 1   Risk Ratio (IV, Fixed, 95% CI) Subtotals only
5.5 Primary: suicide‐related outcomes (continuous) 2   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
5.5.1 End of treatment 2 104 Std. Mean Difference (IV, Random, 95% CI) ‐0.47 [‐1.02, 0.08]
5.5.2 0‐6 months follow‐up 1 28 Std. Mean Difference (IV, Random, 95% CI) ‐0.45 [‐1.20, 0.31]
5.5.3 6‐12 months follow‐up 1 76 Std. Mean Difference (IV, Random, 95% CI) ‐0.44 [‐0.89, 0.02]
5.5.4 Above 12 months follow‐up 1 76 Std. Mean Difference (IV, Random, 95% CI) ‐0.31 [‐0.77, 0.14]
5.6 Primary: psychosocial functioning (continuous) 2   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
5.6.1 End of treatment 1 99 Std. Mean Difference (IV, Random, 95% CI) 0.00 [‐0.39, 0.39]
5.6.2 6‐12 months follow‐up 1 90 Std. Mean Difference (IV, Random, 95% CI) 0.13 [‐0.28, 0.55]
5.6.3 Above 12 months follow‐up 2 209 Std. Mean Difference (IV, Random, 95% CI) 0.04 [‐0.36, 0.43]
5.7 Secondary: interpersonal problems (continuous) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
5.7.1 End of treatment 1 99 Mean Difference (IV, Fixed, 95% CI) 5.40 [‐3.70, 14.50]
5.7.2 6‐12 months follow‐up 1 99 Mean Difference (IV, Fixed, 95% CI) 0.30 [‐9.17, 9.77]
5.7.3 Above 12 months follow‐up 1 76 Mean Difference (IV, Fixed, 95% CI) 11.70 [0.72, 22.68]
5.8 Secondary: dissociation and psychotic‐like symptoms (continuous) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
5.8.1 End of treatment 1 26 Mean Difference (IV, Fixed, 95% CI) ‐2.30 [‐8.84, 4.24]
5.8.2 0‐6 months follow‐up 1 26 Mean Difference (IV, Fixed, 95% CI) ‐13.40 [‐24.49, ‐2.31]
5.9 Secondary: depression (continuous) 5   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
5.9.1 End of treatment 5 314 Std. Mean Difference (IV, Random, 95% CI) ‐0.21 [‐0.77, 0.35]
5.9.2 0‐6 months follow‐up 1 26 Std. Mean Difference (IV, Random, 95% CI) ‐0.96 [‐1.78, ‐0.14]
5.9.3 6‐12 months follow‐up 1 99 Std. Mean Difference (IV, Random, 95% CI) ‐0.29 [‐0.69, 0.11]
5.9.4 Above 12 months follow‐up 2 197 Std. Mean Difference (IV, Random, 95% CI) ‐0.15 [‐0.43, 0.13]
5.10 Secondary: attrition (dichotomous), at end of treatment 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
5.11 Secondary: adverse effects (dichotomous), at end of treatment 2   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
5.11.1 Non‐serious adverse effects 1 306 Risk Ratio (M‐H, Random, 95% CI) 0.92 [0.45, 1.88]
5.11.2 Serious adverse effects 2 326 Risk Ratio (M‐H, Random, 95% CI) 2.65 [0.31, 22.93]