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. 2020 May 4;2020(5):CD012955. doi: 10.1002/14651858.CD012955.pub2

Comparison 22. Cognitive behavioural therapy (CBT) and related treatments vs active treatment.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
22.1 CBT vs trauma‐ and anxiety‐related group psychoeducation (continuous) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
22.1.1 Primary: BPD symptom severity (continuous), at end of treatment 1 50 Mean Difference (IV, Fixed, 95% CI) ‐0.26 [‐1.46, 0.94]
22.1.2 Primary: BPD symptom severity (continuous), at 0‐6 months follow‐up 1 50 Mean Difference (IV, Fixed, 95% CI) ‐0.39 [‐1.60, 0.82]
22.1.3 Primary: BPD symptom severity (continuous), at 6‐12 months follow‐up 1 50 Mean Difference (IV, Fixed, 95% CI) 0.57 [‐0.48, 1.62]
22.1.4 Primary: psychosocial functioning (continuous), at end of treatment 1 50 Mean Difference (IV, Fixed, 95% CI) ‐0.64 [‐5.76, 4.48]
22.1.5 Primary: psychosocial functioning (continuous), at 0‐6 months follow‐up 1 50 Mean Difference (IV, Fixed, 95% CI) ‐1.23 [‐6.94, 4.48]
22.1.6 Primary: psychosocial functioning (continuous), at 6‐12 months follow‐up 1 50 Mean Difference (IV, Fixed, 95% CI) 0.61 [‐5.00, 6.22]
22.1.7 Secondary: depression (continuous), at end of treatment 1 50 Mean Difference (IV, Fixed, 95% CI) 0.76 [‐8.20, 9.72]
22.1.8 Secondary: depression (continuous), at 0‐6 months follow‐up 1 50 Mean Difference (IV, Fixed, 95% CI) 3.13 [‐4.05, 10.31]
22.1.9 Secondary: depression (continuous), at 6‐12 months follow‐up 1 50 Mean Difference (IV, Fixed, 95% CI) 0.77 [‐7.08, 8.62]
22.2 CBT vs trauma‐ and anxiety‐related group psychoeducation, secondary: attrition (dichotomous), at end of treatment 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
22.3 CBT vs interpersonal psychotherapy (IPT) (continuous) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
22.3.1 Primary: psychosocial functioning (continuous), at end of treatment 1 26 Mean Difference (IV, Fixed, 95% CI) ‐5.30 [‐12.36, 1.76]
22.3.2 Secondary: depression (continuous), at end of treatment 1 26 Mean Difference (IV, Fixed, 95% CI) ‐0.40 [‐4.72, 3.92]
22.4 CBT vs IPT, secondary: attrition (dichotomous), at end of treatment 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
22.5 CBT vs Rogerian supportive therapy (continuous) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
22.5.1 Primary: self‐harm (continuous), end of treatment 1 38 Mean Difference (IV, Fixed, 95% CI) 0.74 [‐0.03, 1.51]
22.5.2 Primary: self‐harm (continuous), at 6‐12 months follow‐up 1 21 Mean Difference (IV, Fixed, 95% CI) ‐0.63 [‐1.75, 0.49]
22.5.3 Primary: suicide‐related outcomes (continuous), at end of treatment 1 38 Mean Difference (IV, Fixed, 95% CI) 0.69 [‐2.60, 3.98]
22.5.4 Primary: suicide‐related outcomes (continuous), at 6‐12 months follow‐up 1 21 Mean Difference (IV, Fixed, 95% CI) ‐2.43 [‐6.14, 1.28]
22.5.5 Primary: psychosocial functioning (continuous), at end of treatment 1 38 Mean Difference (IV, Fixed, 95% CI) ‐0.43 [‐1.31, 0.45]
22.5.6 Primary: psychosocial functioning (continuous), at 6‐12 months follow‐up 1 21 Mean Difference (IV, Fixed, 95% CI) ‐0.98 [‐2.02, 0.06]
22.5.7 Secondary: impulsivity (continuous), at end of treatment 1 38 Mean Difference (IV, Fixed, 95% CI) ‐1.01 [‐3.85, 1.83]
22.5.8 Secondary: impulsivity (continuous), at 6‐12 months follow‐up 1 21 Mean Difference (IV, Fixed, 95% CI) ‐2.18 [‐5.91, 1.55]
22.5.9 Secondary: depression (continuous), at end of treatment 1 38 Mean Difference (IV, Fixed, 95% CI) 1.04 [‐5.59, 7.67]
22.5.10 Secondary: depression (continuous), at 6‐12 months follow‐up 1 21 Mean Difference (IV, Fixed, 95% CI) ‐5.15 [‐9.38, ‐0.92]
22.6 CBT vs Rogerian supportive therapy, secondary: attrition (dichotomous), end of treatment 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
22.7 MACT (Manual‐assisted Cognitive Therapy) vs MACT + therapeutic assessment (MACT + TA) (continuous) 1   Mean Difference (IV, Random, 95% CI) Subtotals only
22.7.1 Primary: BPD symptom severity (continuous), at end of treatment 1 16 Mean Difference (IV, Random, 95% CI) ‐3.75 [‐14.17, 6.67]
22.7.2 Primary: self‐harm (continuous), at end of treatment 1 16 Mean Difference (IV, Random, 95% CI) 1.75 [‐18.71, 22.21]
22.7.3 Primary: suicide‐related outcomes (continuous), at end of treatment 1 16 Mean Difference (IV, Random, 95% CI) ‐0.63 [‐17.71, 16.45]
22.7.4 Secondary: affective instability (continuous), at end of treatment 1 16 Mean Difference (IV, Random, 95% CI) ‐5.25 [‐12.10, 1.60]
22.7.5 Secondary: interpersonal problems (continuous), at end of treatment 1 16 Mean Difference (IV, Random, 95% CI) ‐0.50 [‐11.24, 10.24]
22.7.6 Secondary: identity disturbance (continuous), at end of treatment 1 16 Mean Difference (IV, Random, 95% CI) ‐4.88 [‐14.98, 5.22]
22.8 MACT vs MACT + TA, secondary: attrition (dichotomous), at end of treatment 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
22.9 Meta‐Cognitive training for BPD (B‐MCT) vs progressive muscle relaxation training (PMR) 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
22.9.1 Primary: BPD symptom severity (continuous), at end of treatment 1 49 Mean Difference (IV, Fixed, 95% CI) ‐1.80 [‐4.97, 1.37]
22.9.2 Primary: BPD symptom severity (continuous), at 0‐6 months follow up 1 39 Mean Difference (IV, Fixed, 95% CI) ‐3.60 [‐7.16, ‐0.04]
22.9.3 Secondary: depression (continuous), at end of treatment 1 54 Mean Difference (IV, Fixed, 95% CI) ‐3.20 [‐9.91, 3.51]
22.9.4 Secondary: depression (continuous), at 0‐6 months follow‐up 1 47 Mean Difference (IV, Fixed, 95% CI) 8.50 [2.03, 14.97]
22.10 B‐MCT vs progressive muscle relaxation (PMR) training + TAU (dichotomous). Secondary: attrition (dichotomous), at end of treatment 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
22.11 MOTR (Motive‐Oriented Therapeutic Relationship) vs Good Psychiatric Management (GPM) (continuous) 2   Std. Mean Difference (IV, Random, 95% CI) Subtotals only
22.11.1 Primary: BPD symptom severity (continuous), at end of treatment 1 74 Std. Mean Difference (IV, Random, 95% CI) 0.07 [‐0.39, 0.53]
22.11.2 Primary: psychosocial functioning (continuous), at end of treatment 2 99 Std. Mean Difference (IV, Random, 95% CI) ‐0.45 [‐0.85, ‐0.05]
22.11.3 Secondary: interpersonal problems (continuous), at end of treatment 2 99 Std. Mean Difference (IV, Random, 95% CI) ‐0.56 [‐0.97, ‐0.16]
22.12 MOTR vs (GPM), secondary: attrition (dichotomous), at end of treatment 2 110 Risk Ratio (M‐H, Random, 95% CI) 0.61 [0.26, 1.41]