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Key mechanistic analysis of the process using deuterated substrate 45. a) Pd(OAc)2 (10 mol%), t-BuMephos (15 mol%), n-Bu4NOAc (3.0 equiv), toluene, 90°C, 5 h, 95%. b) K2CO3 (5.0 equiv), MeOH, 12 h, 13%. c) Pd(OAc)2 (10 mol%), t-BuMephos (15 mol%), n-Bu4NOAc (3.0 equiv), toluene, 90°C, 5 h, 56%.
