FIG 2.

Plasma viral loads and CD4⁺ T cell counts in rhesus monkeys challenged with original or Env375 pool variants of SHIV-SF162p3, SHIV-AE16, and SHIV-325c. Plasma viral RNA (log RNA copies/ml) are shown for animals that were challenged intravenously with either the parental challenge stocks of SHIV-SF162p3 (A), SHIV-AE16 (B), or SHIV-325c (C) (black lines) or the Env375 pool variants (red line). Dashed lines indicate medians. Percentage of CD4⁺ T cell numbers in peripheral blood are shown. The dotted line reflected the limit of detection of the assay (100 RNA copies/ml). ***, P < 0.001; *, P < 0.05; unpaired t test (parental versus Env375 pool).