TABLE 3.
Cellular mutation analysis of EBNA3A mutant EBV-infected tumorsa
| Gene | Chromosome | Position | Residue(s) in indicated sequence |
Type of alteration | Sample | Frequency in samples infected with: |
||
|---|---|---|---|---|---|---|---|---|
| Reference | Alteration | Δ3A | WT | |||||
| ALG2 | chr9 | 99218509 | AT | A | Frameshift deletion | Δ3A 2 | 0.20 | 0 |
| ASPM | chr1 | 197133436 | A | AT | Frameshift insertion | Δ3A 2 | 0.18 | 0 |
| MBD4 | chr3 | 129436704 | CT | C | Frameshift deletion | Δ3A 1 | 0.19 | 0 |
| SMG1 | chr16 | 18829449 | TG | T | Frameshift deletion | Δ3A 2 | 0.10 | 0 |
a
Mutations present in at least one of the Δ3A tumors that were absent in all the WT tumors.