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. 2020 May 4;94(10):e00035-20. doi: 10.1128/JVI.00035-20

TABLE 1.

RHV class I and II epitopesa

Polyprotein locationb Amino acid sequence MHC class I/II
E1191–199 SAFGTVARF I
E2439–456 SAGWTNLACYGQKGPFLP I
NS3974–982 SICVIGTPL I
NS31299–1316 IQKGRHLIFQTSKSHCDN II
NS31425–1442 IVPDACIYEAFDSGLAYF II
NS31446–1463 PAEVATHLSFYHNQVGLP II
NS31481–1498 YVQSNYLEMMKNRVDSYT II
NS31487–1495 YTYLYAAQY I
NS31502–1519 AAQYQLAKAEGAMAPNDN II
NS4A1578–1586 CVFMAIDLF I
NS4B1747–1764 MVGHAFLTYGSATSACLV II
NS5A2248–2265 MELLREYETSNDHVPKED II
NS5B2486–2503 SGKTEIVKTLYSKLEEGI II
NS5B2511–2519 CVMPKIETF I
NS5B2552–2569 VEKMVLGQIGPKTVKAVC II
NS5B2559–2576 QIGPKTVKAVCGDAYGFV I
a

Epitopes are RT1-Al (class I) or RT1-B/Dl (class II), restricted according to the MHC background of Lewis rats. Boldface indicates novel epitopes identified in this study.

b

Amino acid position according to the start of the RHV polyprotein (GenBank accession no. KX905133; protein cleavage sites predicted in reference 10).