Figure 1.

Neurogenesis in the adult rodent brain. (A) Neurogenesis occurs post-development in the rodent brain in the subgranular zone of the hippocampal dentate gyrus and the subventricular zone surrounding the lateral ventricles (neurogenic regions depicted in red). Immature neurons born in the subventricular zone migrate along the rostral migratory stream (green) to the olfactory bulb. (B–E) NeuN (green) and BrdU (red) staining in coronal sections of the (B) adult mouse olfactory bulb, (C) rostral migratory stream, (D) subventricular zone, and (E) dentate gyrus. The presence of BrdU is indicative of post-developmental neurogenesis in these 4 regions. The inset in (C) is a sagittal view of the rostral migratory stream and the inset in (E) is the dentate gyrus at higher magnification. (F) Sagittal view of the rodent brain depicting neurogenic regions. Regions in which adult neurogenesis has been repeatedly shown to occur are depicted in red, and regions in which there is controversial evidence of low levels of adult neurogenesis are depicted in pink. Reprinted with permission from Zhao et al. (23) for (A–E) and Gould et al. (62) for (F).