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Pharmacologic factors affecting the abuse potential of opioids.
| Physiochemical and Pharmacokinetic | Pharmacodynamic |
|---|---|
| Lipophilicity | Receptor affinity |
| Molecular weight | Dissociation kinetics |
| Chemical form | Development of tolerance to opioid effects |
| Absorption rate constant | |
| Elimination rate constant | |
| Cmax | |
| Tmax | |
| Infusion rate | |
| Protein binding | |
| Route of administration | |
| Bioavailability | |
| Volume of distribution |
