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ToF-SIMS images of an A549 cell exposed to 30 μM platinum complex 2 at 310 K for 3 h. (a,d) Images for [PO3]−, which correspond to the fragment ions of phospholipids and nucleic acids. (b,e) Images for Pt-containing fragment ions [PtCnNn]− (n = 1 or 2) arising from complex 2. (c,f) The corresponding overlapped images of the above. (a–c) correspond to the accumulation of signal from scans 2–7 (cell membrane and cytoplasm), and (d–f) correspond to scans 8–15 (cell nucleus).
