TABLE 5.
Clinical characteristics according to parentality.
| n | Gender | Site onset | Age of onseta | Age at deatha | Durationa | |
| (M/F) | (B/UL/LL/D) | |||||
| ALS | ||||||
| Index cases | 49 | 29/20b | 17/10/21 | 55.2 ± 10.5(49)c | 58.9 ± 10.0(44) | 40.8 ± 24.8(44) |
| Grand parents | 2 | 2/0 | 2/0/0 | 69.0±na(1) | 65.0 ± 9.9(2) | 36.0±na(1) |
| Parents | 39 | 12/27 | 7/2/8 | 62.8 ± 10.4(23) | 64.2 ± 11.4(20) | 41.2 ± 25.0(22) |
| Siblings | 28 | 14/14d | 8/4/8 | 56.4 ± 8.1(21)e | 60.5 ± 8.2(20) | 38.2 ± 24.6(19) |
| ALS/FTD | ||||||
| Index cases | 21 | 13/8 | 8/6/7 | 60.6 ± 7.0(21) | 63.4 ± 7.1(18) | 29.7 ± 18.7(18) |
| Parents | 6 | 2/4 | 3/2/1 | 62.5 ± 6.2(5) | 65.0 ± 6.6(5) | 31.0 ± 18.1(5) |
| Siblings | 10 | 7/3 | 2/0/5/1 | 58.4 ± 7.8(8) | 63.4 ± 6.8(7) | 30.3 ± 20.0(6) |
| FTD | ||||||
| Grand parents | 6 | 2/4 | – | 58.0±na(1) | 62.5 ± 3.5(2) | 84.0±na(1) |
| Parents | 20 | 9/11 | – | 64.8 ± 10.2(7) | 74.0 ± 8.3(10) | 88.1 ± 38.5(7) |
| Siblings | 3 | 3/3 | – | 73.0 ± 1.7(2) | 75.0±na(1) | |
M/F, male/female; B/UL/LL/D, Bulbar/Upper limb/Lower limb/Dementia. aValue are means ± SD (n). bGender ratio vs. parents, p = 0.011. cAge of onset vs. parents, p = 0.005. dGender ratio vs. parent, p = 0.027. eAge of onset vs. parents, not significant.