Table 3.
Linear regression modelsa of the difference in raw BASC-2b scores (Adaptive Skills and Developmental Social Disorders) associated with a two-fold increase in urine concentrations of select biomarkersc among 205d New Bedford Cohort adolescents.
| Overall β (95% CI) |
Males (n=93) β (95% CI) |
Females (n=112) β (95% Cl) |
|
|---|---|---|---|
| Adaptive skillse | |||
| ΣAntiandrogen phthalates | − 9.88 (−16.68, −3.09)f | − 12.52 (−21.85, −3.19)e | − 7.59 (−16.30, 1.11) |
| ΣPersonal care product phthalates | − 3.87 (−8.47, 0.73) | − 3.58 (−9.71, 2.56) | − 4.14 (−10.76, 2.48) |
| ΣDEHP metabolites | − 7.26 (−13.13, −1.39)f | − 12.00 (−20.19, — 3.81)f | − 3.44 (−10.91, 4.02) |
| ΣParabens | − 1.44 (−4.53, 1.64) | − 1.90 (−6.35, 2.56) | − 1.00 (−5.07, 3.06) |
| MHINCH | 0.16 (−1.57, 1.89) | 0.90 (−2.01, 3.82) | − 0.16 (−2.31, 1.99) |
| BPA | 0.77 (−3.59, 5.13) | − 1.80 (−11.54, 7.94) | 1.29 (−3.24, 5.81) |
| BPS | − 1.63 (−5.17, 1.92) | 3.25 (−5.52, 12.01) | − 2.79 (−6.42, 0.84) |
| BPF | − 0.50 (−1.64, 0.64) | − 0.82 (−2.80, 1.17) | − 0.28 (−1.72, 1.16) |
| Developmental Social Disorders (DSD)e | |||
| ΣAntiandrogen phthalates | 1.44 (0.35, 2.54)f | 1.87 (0.41, 3.33)f | 1.07 (−0.38, 2.52) |
| ΣPersonal care product phthalates | 0.58 (−0.18, 1.35) | 0.56 (−0.45, 1.57) | 0.60 (−0.46, 1.67) |
| ΣDEHP metabolites | 1.08 (0.13, 2.03)f | 1.81 (0.50, 3.12)f | 0.49 (−0.73, 1.71) |
| ΣParabens | 0.13 (−0.38, 0.65) | 0.18 (−0.56, 0.92) | 0.09 (−0.58, 0.77) |
| MHINCH | − 0.07 (−0.34, 0.20) | − 0.25 (−0.72, 0.22) | 0.01 (−0.32, 0.35) |
| BPA | − 0.03 (−0.73, 0.68) | 0.22 (−1.37, 1.81) | − 0.08 (−0.80, 0.65) |
| BPS | 0.30 (−0.26, 0.86) | − 0.54 (−1.93, 0.84) | 0.50 (−0.08, 1.08) |
| BPF | 0.05 (−0.14, 0.23) | 0.02 (−0.31, 0.35) | 0.07 (−0.17, 0.30) |
Adjusted for maternal characteristics at birth: age, marital status, education, household income, and alcohol intake and smoking during pregnancy; child: race, sex, age at BASC-2, and, during the 24 h prior to urine collection, personal care product use, fast food consumption, and food or drink microwaved in plastic.
Behavior Assessment System for Children, Second Edition -Teacher Rating Scale.
Concentrations were calculated as follows: ΣAntiandrogen phthalates (μmol/L): molar sum of MEHHP, MEHP, MEOHP, MECPP, MBP, MiBP, MBzP, MHiBP, MCOP, MNP, and MHBP (MCOP and MNP, were down weighted by multiplying their molar concentrations by 0.43 prior to summing to reflect the potency of their parent compound relative to the other anti-androgenic phthalates); ΣPersonal Care Product phthalates (μmol/L): molar sum of MBP and MEP; ΣDEHP metabolites (μmol/L): molar sum of MECPP, MEHHP, MEOHP, MEHP; ΣParabens (μmol/L): molar sum of B-Paraben, E-Paraben, M-Paraben, and P-Paraben. Units for sums are μmol/L; units for individual biomarkers are μg/L.
Sample size of 205 after imputation for missing data.
A lower score on Adaptive Skills and a higher score on DSD indicate more maladaptive behavior.
p-value< 0.05.