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In a cell culture model HUT-78, the binding of NF-κB to DNA, an essential transcription factor for gene expression of Th1 cytokines (IL-2 and IFN-γ), is regulated by zinc as shown in this figure. We also show that the other transcription factors essential for gene expression of Th1 cytokines, AP1 and SP1, are also zinc dependent and their binding to DNA is regulated by zinc [35].
