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Our results of activation of NF-κB by zinc in HUT-78, a cell culture model. We observed that zinc was required for the expression of p105 mRNA, a precursor of p50 NF-κB protein. Once expressed, p50 NF-κB binds to IκB in the plasma. Following phosphorylation of IκB by zinc, NF-κB 50 is released for binding to DNA and gene expression of various proteins such as IL-2, IL-2Rα and β, IFN-γ, and IκB-α.
