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α-Lipoic acid (ALA) was administered daily for 7 d prior to a reperfused, 45-minute coronary occlusion. Two doses were examined: 15 and 75 mg/kg·day. Mean infarct size (% risk region) in ALA-treated mice was reduced by a minimum of 30% relative to control mice. ∗P < 0.05 as compared with the H2O-treated group.
