Figure 2.

(a) Plasma malondialdehyde (MDA) levels were assessed 2 h and 24 h post-AMI. At 2 h post-AMI, MDA levels in either treatment group (15 or 75 mg/kg·day ALA) were reduced by over 40% relative to control (P < 0.05, either comparison). Twenty-four hours after AMI, MDA levels in either treatment group were reduced by nearly 70% relative to control (P < 0.05, either comparison). (b) Total plasma nitrate/nitrite 24 hours post-AMI was also reduced to control levels after 7-day pretreatment with 75 mg/kg·day ALA. (c) Myeloperoxidase activity in the infarct zone 24 hours post-AMI was reduced to control levels by 7-day pretreatment with 75 mg/kg·day ALA. ^∗P < 0.05 as compared with the H₂O-treated group.