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. 2015 Jul;93(7):3661–3674. doi: 10.2527/jas.2015-9023

Table 3.

Effects of ancillary therapies used in combination with an antimicrobial on performance, retreatment percentages, and retreatment intervals

Variable Experimental ancillary treatment1 Pooled SEM Overall P-value2
NOAC NSAID VACC VITC
Treatment BW,3 kg
    First treatment 215 214 212 213 3.32 0.78
    Second treatment 214 209 212 212 6.97 0.82
    Third treatment 211a 192b 192b 192b 5.63 0.01
    Fourth treatment 193 181 190 194 12.1 0.60
Average daily gain,4 kg
    First to second −0.54 −0.48 −0.61 −1.01 0.40 0.63
    Second to third −0.13a −1.30b −1.90b −1.41b 0.42 <0.01
    Third to fourth −0.31 −0.28 −0.48 −0.45 0.72 0.99
    First to fourth −0.89 −0.97 −1.16 −1.01 0.34 0.94
Retreatments,5 %
    Second treatment 48.8 51.3 37.5 43.8 11.4 0.26
    Third treatment 55.1 42.7 50.4 44.7 13.5 0.67
    Fourth treatment 29.7a,x 35.7a,y 59.2y,z 67.2b,z 12.1 0.05
    Third treatment, % of first 30.0 25.0 21.3 22.5 9.63 0.54
    Fourth treatment, % of first 8.75 8.75 12.5 15.0 5.48 0.50
Time to treatment,6 d
    First treatment 7.53 7.28 7.30 7.27 1.36 0.82
    Second treatment 19.4 16.7 18.0 16.9 3.34 0.31
    Third treatment 26.4a 18.2b 18.3b 17.9b 2.22 <0.001
    Fourth treatment 31.0 26.7 24.7 25.8 2.66 0.30

a,bWithin a row means with different superscripts differ (P ≤ 0.05).

x–zWithin a row means with different superscripts tend to differ (P ≤ 0.10).

1Experimental ancillary therapy treatments administered at each antimicrobial treatment for bovine respiratory disease: NOAC = antimicrobial only, no ancillary therapy; NSAID = intravenous flunixin meglumine injection; VACC = revaccination with an intranasal viral vaccine; VITC = intramuscular vitamin C injection.

2 P-values are included for the overall F test.

3Treatment BW was the BW in kilograms with a calculated 2% shrink at the time of bovine respiratory disease (BRD) treatment.

4Treatment ADG was calculated from the shrunk (2%) BW in kilograms and individual days on feed between the BRD treatments.

5Retreatment percentages were calculated by taking the number of calves treated for BRD divided by the number of calves treated for BRD the previous time in the case of second treatment, third treatment, and fourth treatment or by taking the number of calves treated for BRD divided by the number of calves treated for BRD initially in the case of third treatment percentage of first and fourth treatment percentage of first.

6Average length of time in days from arrival until the BRD treatment.