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. 2020 May 3;11(1):391–397. doi: 10.1080/21505594.2020.1759287

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — InlA and InlB dependent breaching of the placental barrier by Listeria monocytogenes.

(a) The placental barrier between the maternal blood and the fetus lies in an epithelium, the syncytiotrophoblast, which results from the fusion of underlying cytotrophoblast cells. Syncytiotrophoblast expresses E-cadherin, which is accessible for bacteria in the maternal blood. (b) Listeria monocytogenes adheres to syncytiotrophoblast via InlA interaction with Ecad. InlB is required for L. monocytogenes entry by activating PI3-K via c-Met in the syncytiotrophoblast, leading to the actin cytoskeleton rearrangements needed for bacterial internalization.