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. 2020 Feb 16;7(3):1697619. doi: 10.1080/23723556.2019.1697619

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 1. — Metabolic pathways affected by mutant SF3B1. Blue asterisks indicate metabolites that were found to be downregulated by SF3B1^MUT. Green asterisks show metabolic proteins found to be misspliced and downregulated by SF3B1^MUT. 3PG = 3-phosphoglycerate. PHP = phosphohydroxypyruvate. pSer = phosphoserine. I, II, III, IV, V = mitochondrial complexes. Fe-S = iron-sulfur complex. MMA = methylmalonyl. ALA = aminolevulinic acid. PPgIX = protoporphyrinogen IX. PPIX = protoporphyrin IX. PHGDH = phosphoglycerate dehydrogenase. UQCC1 = ubiquinol-cytochrome c reductase complex assembly factor 1. DLST = dihydrolipoamide S-succinyltransferase. MUT = methylmalonyl-CoA mutase. ABCB7 = ATP binding cassette subfamily B member 7. PPOX = protoporphyrinogen oxidase.