Table 3.
Differential infiltration of immune cells across patient subgroups.
| Cohort | Cell type | Infiltration fraction | P value |
|---|---|---|---|
| Survival risk (low vs high) | M2 Macrophages | 0.1020 vs 0.1425 | 3.60e-61 |
| Survival risk (low vs high) | M1 Macrophages | 0.0716 vs 0.0471 | 2.90e-54 |
| Survival risk (low vs high) | Follicular helper T cells | 0.0785 vs 0.0543 | 9.00e-42 |
| Survival risk (low vs high) | Activated memory CD4 T cells | 0.0198 vs 0.0062 | 1.70e-28 |
| Survival risk (low vs high) | Resting memory CD4 T cells | 0.0509 vs 0.0745 | 1.00e-23 |
| Survival risk (low vs high) | Monocytes | 0.0316 vs 0.0174 | 1.60e-20 |
| Survival risk (low vs high) | Naive B cells | 0.0132 vs 0.0241 | 4.30e-17 |
| Survival risk (low vs high) | Resting dendritic cells | 0.0238 vs 0.0120 | 8.30e-15 |
| Survival risk (low vs high) | Neutrophils | 0.0104 vs 0.0169 | 4.50e-14 |
| Survival risk (low vs high) | Gamma delta T cells | 0.0112 vs 0.0216 | 2.80e-13 |
| Survival risk (low vs high) | Eosinophils | 0.0016 vs 0.0044 | 9.90e-13 |
| Survival risk (low vs high) | M0 Macrophages | 0.0724 vs 0.0541 | 1.80e-12 |
| Survival risk (low vs high) | Regulatory T cells | 0.0278 vs 0.0191 | 5.50e-11 |
| Survival risk (low vs high) | Activated mast cells | 0.0166 vs 0.0246 | 1.30e-07 |
| Survival risk (low vs high) | Naive CD4 T cells | 0.0022 vs 0.0002 | 4.60e-06 |
| Survival risk (low vs high) | Resting NK cells | 0.0084 vs 0.0050 | 3.40e-05 |
| Survival risk (low vs high) | CD8 T cells | 0.0633 vs 0.0543 | 0.00043 |
| Survival risk (low vs high) | Resting mast cells | 0.0177 vs 0.0205 | 0.024 |
| Grade (low vs high) | M1 Macrophages | 0.0392 vs 0.0600 | 2.40e-06 |
| Grade (low vs high) | Follicular helper T cells | 0.0474 vs 0.0675 | 1.90e-05 |
| Grade (low vs high) | Activated NK cells | 0.0346 vs 0.0421 | 0.030 |
| Grade (low vs high) | Resting memory CD4 T cells | 0.0783 vs 0.0623 | 0.049 |
| Stage (early vs late) | Activated mast cells | 0.0136 vs 0.0215 | 0.00012 |
| Stage (early vs late) | Activated NK cells | 0.0367 vs 0.0428 | 0.0082 |
| Stage (early vs late) | Activated memory CD4 T cells | 0.0191 vs 0.0122 | 0.011 |
| Type (I vs II) | M1 Macrophages | 0.0456 vs 0.0606 | 7.60e-08 |
| Type (I vs II) | Follicular helper T cells | 0.0586 vs 0.0680 | 0.0015 |
| Type (I vs II) | Activated NK cells | 0.0375 vs 0.0426 | 0.021 |
| Type (I vs II) | Activated dendritic cells | 0.0221 vs 0.0276 | 0.024 |
| Status (E vs M) | Regulatory T cells | 0.0282 vs 0.0190 | 1.20e-11 |
| Status (E vs M) | Resting mast cells | 0.0151 vs 0.0227 | 4.00e-10 |
| Status (E vs M) | Activated dendritic cells | 0.0314 vs 0.0217 | 1.90e-09 |
| Status (E vs M) | M2 Macrophages | 0.1154 vs 0.1294 | 4.50e-08 |
| Status (E vs M) | Resting memory CD4 T cells | 0.0563 vs 0.0690 | 9.30e-08 |
| Status (E vs M) | Follicular helper T cells | 0.0694 vs 0.0630 | 0.00041 |
| Status (E vs M) | Naive B cells | 0.0164 vs 0.0210 | 0.00061 |
| Status (E vs M) | Gamma delta T cells | 0.0139 vs 0.0189 | 0.00062 |
| Status (E vs M) | Resting NK cells | 0.0079 vs 0.0055 | 0.0041 |
| Status (E vs M) | Eosinophils | 0.0026 vs 0.0035 | 0.012 |
| Status (E vs M) | Memory B cells | 0.0261 vs 0.0222 | 0.015 |
| Status (E vs M) | Monocytes | 0.0226 vs 0.0258 | 0.031 |
Only immune cells with significantly differential infiltration between patient subgroups were shown.