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. 2020 Apr 28;13:54. doi: 10.3389/fnmol.2020.00054

FIGURE 6.

FIGURE 6

GAT211 does not alter conditioned place preference to morphine. Morphine (8 mg/kg i.p. × 4 pairings) increases the time spent in the drug-paired chamber relative to the vehicle-paired chamber on the test day (A). The combination of GAT211 (20 mg/kg i.p.) and morphine (8 mg/kg i.p.) produces CPP relative to the vehicle-paired chamber on the test day (B). No difference in chamber preference times were observed pre-conditioning (baseline) in any study (A–C). Vehicle-vehicle pairings do not result in preference for any chamber (C). Chamber preference scores did not differ reliably in mice receiving morphine alone or morphine in combination with GAT211 (two-tailed t-test using Welch’s correction) (D). Testing for conditioned place preference/aversion was performed on day 12 in a drug-free state. Data are expressed as mean ± SEM (n = 10 per group). **P < 0.01, ****P < 0.001 vs. vehicle-paired chamber, two-way ANOVA followed by Bonferroni’s post hoc test. n.s., non-significant.