Table 5.

Effects of dEB and CA on aquaporins, ion transporters, cytokines, and tight junction proteins of jejunum in weaned piglets¹

	0% CA				0.3% CA
	dEB, mEq/kg				dEB, mEq/kg					P-value
Item2	−50	100	250	400	−50	100	250	400	SEM	CA3	dEB	CA×dEB
AQP3	1.07	0.97	1.21	0.91	0.71	0.90	0.85	1.16	0.07	0.390	0.886	0.441
AQP8	1.25	1.33	1.14	1.27	1.76	1.43	0.93	1.10	0.13	0.831	0.598	0.756
NKCC1	1.11	0.68	0.66	0.74	0.53	0.72	0.43	0.65	0.06	0.066	0.400	0.282
NHE3	1.02	1.26	0.76	1.00	0.76	0.97	0.84	0.91	0.05	0.197	0.202	0.589
CFTR	1.02	1.43	0.94	1.00	0.48	0.79	0.80	0.90	0.09	0.047	0.530	0.587
TNF-α	1.07	0.94	0.55	0.69	0.36	0.53	0.29	0.50	0.06	＜0.001	0.075	0.238
IFN-γ	1.06	1.09	0.71	1.14	0.35	0.92	0.19	0.46	0.08	＜0.001	0.044	0.510
IL-1β	1.02	1.36	0.66	1.03	0.39	1.00	0.43	0.53	0.09	0.011	0.047	0.838
IL-10	1.04	1.19	0.59	0.92	0.39	0.78	0.32	0.47	0.07	＜0.001	0.023	0.734
Occludin	1.04	0.78	0.75	1.17	0.58	0.79	0.67	0.78	0.06	0.042	0.351	0.344
ZO-1	1.02	0.84	0.65	0.84	0.51	0.75	0.60	0.74	0.04	0.028	0.396	0.195
Claudin-1	1.04	1.94	1.17	1.62	0.76	1.59	0.94	1.32	0.10	0.136	0.011	0.997

¹Data were means of seven piglets per treatment.

²AQP3, aquaporin 3; AQP8, aquaporin 8; NHE3, Na+/H+ exchanger 3.

³CA × dEB = the interaction between citric acid and dietary electrolyte balance.