TABLE 1.

In vitro anticancer effects of citrus peel extract¹

Sample	Compound identification	Cell lines (IC50, µg/mL)	Cell cycle arrest	Antiproliferation	Proapoptosis	Antimetastasis	Anti-inflammatory and antiangiogenesis	Reference
Citrus reticulata	D	WEHI 3B (<100)	—	—	—	—	—	106, 107
C. reticulata	—	SNU-668 (∼100)	—	—	I	—	—	108
C. sinensis	D	MCF-7 (10.2–17.9)	—	—	I	—	—	109
C. grandis	D	U937 (60), HepG2 (31), HeLa (287), HCT-15 (87), MCF-7 (110), NCI-H460 (73), SNU-16 (90)	—	—	I*	—	—	68
17 citrus varieties	D	HT-29 (31–45)	—	—	—	—	—	110
C. sunki	D	HL-60 (25)	G2/M	—	I	—	—	53
C. aurantium	D	AGS (40–60)	G2/M	I	I	—	—	38
C. aurantium	—	U937 (40–60)	—	—	I	I	—	111
C. grandis	D	HeLa (100–200), AGS (200–400)	—	—	I	—	—	70
C. aurantium	D	A549 (230)	G2/M	I	I	—	—	39
C. unshiu	—	MDA-MB-231(>200)	—	—	—	I	—	112
C. junos	—	HT-29 (>1200)	—	—	—	—	I	113
C. aurantifolia	—	MCF-7 (59)	G2/M	—	I	—	—	114
C. aurantium	D	A549	—	—	I	I	—	40
C. hassaku	D	MDA-MB-231	—	—	—	I	—	113
C. reticulata	D	HepG2 (20–40), HL-60 (25–50), MDA-MB-231 (25–50)	—	—	—	—	—	42
C. paradisi, C. sinensis, C. maxima	D	Caco-2, LoVo, LoVo/ADR	—	—	—	—	—	115
C. hassaku	D	SNU-1 (<25)	G1	—	I	—	—	116
C. paradisi		Kasumi-1 (2000)	—	—	I	—	—	117
C. reticulata	D	SKOV3 (∼100)	—	—	I	I		118
C. platymamma	D	A549 (364)	G2/M	I	I	—	I	86
C. sphaerocarpa	D	MDA-MB-231 (>200)	—	—	—	I	I	113
C. iyo	D	U266 (>400), K562 (200–400), DU145 (>400), MDA-MB-231 (>400), HepG2 (200–400), RWPE-1 (>400)	—	I^	I^	I^	I^	75
C. platymamma	D	Hep3B (100–200), HepG2 (300–400)	G2/M	I#	I#	I#	—	119
C. sinensis	D	HepG2 (>500)	G1	I	I	—	—	120
C. reticulata	—	HCT116	—	—	—	—	—	121

¹D, determined; I, induced; *only for U937; ^only for DU145; ^#only for Hep3B.