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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Trends Cancer. 2020 Jan 23;6(3):247–260. doi: 10.1016/j.trecan.2019.12.009

FIGURE 2. THE BIOGENESIS AND FUNCTION OF APBs.

FIGURE 2.

SUMOylation of Shelterin components, TRF1 and TRF2, recruits PML/SP100 via SUMO-SIM interactions. SUMOylation-induced APB condensates lead to clustering of telomeres and DNA repair factors within the PML/SP-100 shell. A positive SUMOylation feedback loop enhances APB formation. APBs act as a platform to concentrate repair and recombination factors to perhaps facilitate telomeric DNA synthesis, particularly of extra-chromosomal C-circles. APBs are subsequently disassembled as a result of deSUMOylation events.