Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 1;368(6498):1499–1504. doi: 10.1126/science.abc1560

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

PMC Copyright notice

Fig. 1 — (A) Schematic diagram for the components of the RdRp complex, containing nsp12, nsp7, and nsp8. The polymerase motif (A to G) and the β hairpin specific to SARS-CoV-2 are highlighted. (B) Sequence of the RNA duplex with a 5′ U₁₀ overhang as a template for primer extension and RdRp-RNA complex assembly. (C) The recombinant RdRp complex shows polymerase activity in vitro. The primer strand is labeled with fluorescence at the 5′ end. (D) Elongation of the partial RNA duplex by the purified RdRp complex and its inhibition by RTP.