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. 2020 Apr 23;16(4):e1007822. doi: 10.1371/journal.pcbi.1007822

Fig 4. State-dependent population response to time-varying input currents.

Fig 4

Population rates of the excitatory population (black) with an additional external electrical stimulus (red) applied to the excitatory population. (a, b) A DC step input with an amplitude of 60 pA (equivalent E-field amplitude: 12 V/m) pushes the system from the low-activity fixed point into the fast limit cycle LCEI. (c, d) A step input with amplitude 40 pA (8 V/m) pushes the system from LCEI into the up-state. (e, f) In the multistable region bi, a step input with amplitude 100 pA (20 V/m) pushes the system from the down-state into the up-state and back. (g, h) Inside the slow oscillatory region LCaE, an oscillating input current with amplitude 40 pA and a (matched) frequency of 3 phase-locks the ongoing oscillation. (i, j) A slow 4 Hz oscillatory input with amplitude 40 pA drives oscillations if the system is close to the oscillatory region LCaE. For the AdEx network, N = 100 × 103. All parameters are given in Table 1. The parameters of the points of interest are given in Table 2.