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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Kidney Int. 2019 May 22;96(4):957–970. doi: 10.1016/j.kint.2019.05.007

Figure 6. Podocyte derived endothelin-1 in DoxSN induced degradation and remodeling of ESL via EdnrA and mitochondrial ROS.

Figure 6

(A) mRNA expression for Hpse and Hyal2 of control and Edn1 +/− BQ-123 treated PodTgfbr1 podocytes. (B) mRNA expression of Hpse, Hyal2, Ext1, Hs2st1 of control mGEC, and mGECs treated with Edn1, PodTgfbr1 supernatants (CtrlSN and DoxSN), DoxSN+mTe, DoxSN+BQ-123 for 48hr (+/−SD *P <0.05, **P <0.01, compared to mGEC Ctrl, ud=undetectable). (C) Cell surface heparan sulfate and (D) Isolectin B4 of control mGEC, and mGECs treated Edn1, PodTgfbr1 supernatants (CtrlSN and DoxSN), DoxSN+mTe, DoxSN+BQ-123 for 48hr assessed by FACS.