Figure 2.

Association analysis between cell-associated (CA) unspliced (US) and plasma human immunodeficiency virus (HIV) ribonucleic acid (RNA) in HIV/hepatitis C virus-coinfected individuals treated with direct-acting antivirals (DAA). The CA US-RNA as well as plasma HIV RNA were evaluated in coinfected individuals before treatment initiation (baseline [BSL]), at the end of treatment (EOT), and 12 months after finalizing DAA therapy (12MPT). Relationship between variables was measured by applying a generalized linear mixed-effects model with plasma RNA as the independent variable and CA US-RNA and time as fixed-effect predictors; P value for the CA US-RNA coefficient is shown. White, gray, and black filled dots represent individual measures belonging to BSL, EOT, and 12MPT subgroups, respectively.