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. 2020 May 5;9:e54781. doi: 10.7554/eLife.54781

Figure 3. In rats, CIM6P/IGF2R is required for memory consolidation, but not learning or memory retrieval.

Figure 3.

Experimental timelines are shown above graphs. Rats were injected with IgG or anti-CIM6P/IGF2R antibody 15 min before IA training or testing (↑). Inhibitory avoidance training and memory retention are expressed as mean latency ± SEM (in seconds). (a) The effect of a single injection of anti-CIM6P/IGF2R on memory retention in animals trained (Tr) with a stronger, (0.9 mA) shock intensity (n = 6, two independent experiments). (b) The effect of anti-CIM6P/IGF2R on memory tested 5 min after training (n = 6, two independent experiments), or 1 hr after training (c) n = 6, two independent experiments). (d) Open field test was conducted 24 hr after IA training; total distance travelled, average travel velocity, and cumulative time spent in the center of the arena were recorded (n = 8, two independent experiments). (e) The effect of anti-CIM6P/IGF2R on memory retrieval: anti-CIM6P/IGF2R was injected 15 min before memory test given 1 day after IA training (n = 6, two independent experiments). Two-way repeated measures ANOVA followed by Sidak’s post hoc tests. ****p<0.0001; see Source data one for detailed statistical information.