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. 2020 May 4;9:e55692. doi: 10.7554/eLife.55692

Table 2. Gene Ontology (GO) functional annotation of differentially expressed genes in naïve- or hk-MTB-stimulated cells treated with PZA or RIF.

hk-MTB + PZA
GO category avg. LogFC p-value
Integral to lumenal side of endoplasmic reticulum membrane 0.16 2.79E-04
Cytokine-mediated signaling pathway 0.27 3.28E-04
Interferon-gamma-mediated signaling pathway 0.21 3.56E-04
MHC class I receptor activity 0.16 7.82E-04
Cytosolic small ribosomal subunit 0.26 7.98E-03
MHC class I protein complex 0.16 1.04E-03
Regulation of immune response 0.22 1.33E-03
Negative regulation of MAPK cascade 0.20 1.34E-03
Naïve + RIF
GO category avg. LogFC p-value
Mitotic cell cycle -0.37 1.53E-17
DNA replication -0.34 2.59E-13
Cell cycle checkpoint -0.36 4.98E-10
S phase of mitotic cell cycle -0.32 6.29E-10
DNA strand elongation involved in DNA replication -0.33 1.88E-09
G1/S transition of mitotic cell cycle -0.36 2.02E-09
Cell division -0.34 3.96E-09
Cell cycle -0.32 2.26E-07
hk-MTB + RIF
GO category avg. LogFC p-value
Melanosome 0.26 4.09E-07
Endoplasmic reticulum unfolded protein response 0.29 7.95E-07
Electron carrier activity 0.23 9.11E-07
Tissue regeneration -0.23 1.63E-05
Response to drug -0.29 2.32E-05
NADP binding 0.22 3.07E-05
Cellular lipid metabolic process -0.19 4.05E-05
Lipid metabolic process -0.23 4.98E-05