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. 2020 May 5;9:e54160. doi: 10.7554/eLife.54160

Figure 3. FICI scores of structurally similar molecules.

Figure 3.

Chemical structure of (A) dicyclomine HCl and structurally similar molecules (B) proadifen, (C) drofenine, and (D) naftidrofuryl. Chemical structure of (E) desipramine HCl and structurally similar molecules (F) impramine, (G) mianserine, and H) lofepramine. Chemical structure of (I) sertraline HCl and structurally similar (J) sibutramine. Chemical structure of (K) diphenhydramine HCl and structurally similar (L) citalopram. (M) Fractional inhibitory concentration index (FICI) score of structurally similar molecules. Synergistic interactions with FLZ labeled in green and non-interacting molecules labeled in grey. * represents FICI for 50% inhibition of C. neoformans strain CM18 all others listed are FICI for 90% inhibition. Average FICI scores represent a minimum of two independent replicates. All average FICI scores represent an average of at least two independent tests. Source data are Figure 3—source data 1.

Figure 3—source data 1. FICI scores of small molecules with structures similar to newly identified fluconazole-synergizers.
FICI scores for small molecules listed in combination with fluconazole. All scores are for FICI 90% inhibition unless listed. *=FICI scores for 50% inhibition (when 90% inhibition of fungal growth could not be obtained.