Table 3.
SARS-CoV-2-derived HLA-class I epitopes with high coverage of Japanese population based on HLA-A frequency
| Protein | Position in protein | Peptide length | Peptide sequence | Population coveragea | |||||
|---|---|---|---|---|---|---|---|---|---|
| HLA-A | HLA-B | HLA-C | |||||||
| ORF1ab | 2168 | 9 | YMPYFFTLL | 83.8% | A*02:01, A*02:06, A*24:02 | 0.0% | – | 76.5% | C*01:02, C*08:01, C*12:02, C*14:02 |
| ORF1ab | 4089 | 10 | FTYASALWEI | 83.8% | A*02:01, A*02:06, A*24:02 | 22.0% | B*52:01 | 22.2% | C*12:02 |
| ORF1ab | 3653 | 10 | VYMPASWVMR | 75.7% | A*24:02, A*31:01, A*33:03 | 0.0% | – | 0.0% | – |
| S | 448 | 10 | NYNYLYRLFR | 75.7% | A*24:02, A*31:01, A*33:03 | 0.0% | – | 0.0% | – |
| ORF1ab | 3654 | 10 | YMPASWVMRI | 75.1% | A*02:01, A*24:02 | 14.1% | B*51:01 | 0.0% | – |
| ORF1ab | 1674 | 10 | CYLATALLTL | 75.1% | A*02:01, A*24:02 | 0.0% | – | 0.0% | – |
| ORF1ab | 6418 | 10 | LYLDAYNMMI | 75.1% | A*02:01, A*24:02 | 0.0% | – | 0.0% | – |
| S | 268 | 10 | GYLQPRTFLL | 75.1% | A*02:01, A*24:02 | 0.0% | – | 0.0% | – |
| ORF3a | 106 | 10 | LYLYALVYFL | 75.1% | A*02:01, A*24:02 | 0.0% | – | 0.0% | – |
| ORF1ab | 3605 | 10 | FLYENAFLPF | 72.3% | A*02:06, A*24:02 | 24.3% | B*15:01, B*46:01 | 74.7% | C*03:04, C*07:02, C*08:01, C*12:02, C*14:03 |
| ORF1ab | 3126 | 10 | IQWMVMFTPL | 72.3% | A*02:06, A*24:02 | 33.4% | – | 0.0% | – |
aCalculated based on the allele frequency of HLA (Supplementary Table 1)