Table 4.

Mutations frequently (≥10%) observed in SARS-CoV-2 isolated from four different regions

Protein	Position in protein	Reference amino acida	Mutant amino acid	Mutation frequency
				Asia (N = 587)	North America (N = 1918)	Europe (N = 3190)	Oceania (N = 726)
ORF1ab	265	T	I	0.0346	0.424	0.104	0.171
ORF1ab	3606	L	F	0.248	0.0438	0.178	0.17
ORF1ab	4715	P	L	0.154	0.587	0.737	0.526
ORF1ab	5828	P	L	0	0.306	0.00599	0.0783
ORF1ab	5865	Y	C	0	0.314	0.00530	0.0805
S	614	D	G	0.155	0.586	0.736	0.526
ORF3a	57	Q	H	0.0426	0.489	0.142	0.204
ORF3a	251	G	V	0.0991	0.0256	0.172	0.121
ORF8	84	L	S	0.222	0.351	0.0295	0.206
N	13	P	L	0.0171	0.00313	0.00126	0.105
N	203	R	K	0.0532	0.0365	0.276	0.148
N	204	G	R	0.0532	0.0355	0.276	0.147

^aProtein sequence based on the reference SARS-CoV-2_Wuhan-Hu-1 sequence (GenBank accession number MN908947)