Table 2.
Proportion of Mirabegron Initiations with Severe and Non-Severe Uncontrolled Hypertension Relative to DHPC Dissemination
| Netherlands | Spain | UK | Finland | ||
|---|---|---|---|---|---|
| Severe uncontrolled hypertension | Pre-DHPC % (95% CI) | 0.61 (0.40–0.89) | 0.33 (0.24–0.45) | 0.46 (0.34–0.62) | 1.29 (0.94–1.73) |
| Post-DHPC % (95% CI) | 0.26 (0.11–0.50) | 0.42 (0.28–0.60) | 0.44 (0.30–0.62) | 1.86 (1.47–2.34) | |
| Estimated absolute % changea | −0.36 (p=0.053) | 0.12 (p=0.301) | −0.15 (p=0.251) | 0.73 (p=0.016) | |
| Non-severe uncontrolled hypertension | Pre-DHPC % (95% CI) | 15.84 (14.78–16.95) | 12.54 (11.97–13.13) | 14.95 (14.26–15.67) | 12.95 (11.84–14.13) |
| Post-DHPC % (95% CI) | 13.80 (12.61–15.06) | 11.38 (10.66–12.14) | 15.65 (14.83–16.49) | 13.46 (12.41–14.56) | |
| Estimated absolute % changea | −2.02 (p=0.038) | −1.04 (p=0.071) | 0.75 (p=0.188) | −1.91 (p=0.219)b |
Notes: aEstimated absolute change is calculated as the projected counterfactual proportion – predicted proportion based on the best fit model at the mid-point of post-DPHC period (as indicated in Figure 2). bp-value pertains to change in level; time trend was retained in the model with p=0.034
Abbreviations: BP, blood pressure; IQR, interquartile range.