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. 2020 May 1;15:3057–3070. doi: 10.2147/IJN.S238265

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© 2020 Patil et al.

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Evaluation of NCA for contrast enhancement in GBM.

Notes: MRI brain scans of mice with EGFR+ tumor, (A) GBM (U87MG) in the right hemisphere after iv injection of targeted NCAs (for NIA-Gd1). Scans were taken before (no contrast, 0 minutes) and 20 minutes, 1, 2 and 3 hours after injection of NCAs. Black dots in some MRI scans shows the drill hole in the skull made for inoculation of tumor cells. (B) Quantitative analysis of MRI contrast in tumors. High contrast in the targeted GBM tumor was maintained for several hours with the highest contrast noticed for NCA-Ab-Gd3. Three animals were used for each NCA.

Abbreviations: EGFR, epidermal growth factor receptor; NCA, nano contrast agent; GBM, glioblastoma multiforme.