Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 1;15:3087–3098. doi: 10.2147/IJN.S241324

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Zhou et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

Notes: Antitumor effect of CS-4D5/6e in a 22Rv1 xenograft model. (A) Reduction in prostate tumour volume in each group for 14 days after administration. (n = 6, means ± SD, **P < 0.01). (B) Serum testosterone levels of nude mice in each group for 14 days after administration. (C) Comparison of AKR1C3 expression levels in 22Rv1 xenografted nude mice by Western blot analysis, using rabbit monoclonal anti-AKR1C3 antibody and α-tubulin as a loading control. The dose of INN was 3 mg/kg and that of 6e was 2.5 mg/kg. (D) Western blot and analysed by greyscale scanning AKR1C3 (n = 6, mean ± SD, ns: no significant difference vs vehicle, P > 0.05).

Abbreviations: PBS, phosphate buffered saline; INN, indomethacin; CS, chemically chitosan; 4D5, single chain antibody fragment 4D5; 6e, a derivative of mansonone F; AR, androgen receptor; AKR1C3, aldo-ketoreductase1C3; SD, standard deviation.