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. 2020 May 1;13:3689–3701. doi: 10.2147/OTT.S238338

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© 2020 Yin et al.

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MiR-122-5p inhibitor relieved the restraint effects on cell proliferation, colony formation, migration, and invasion in HT-29 and HCT-116 cells induced by CDC25A knockdown. (A–F) The HT-29 and HCT-116 cells were transfected with si-NC, si-CDC25A, si-CDC25A + anti-miR-NC or si-CDC25A + anti-miR-122-5p. (A) The level of CDC25A was examined by qRT-PCR. (B) The protein level of CDC25A was tested via Western blot assay. (C) The cell viability was monitored by MTT assay. (D) The colony-forming ability was assessed via colony formation assay. (E,F) The migrated and invaded abilities were examined by Transwell assay. *P<0.05 **P<0.01.