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. 2020 May 1;15:3039–3056. doi: 10.2147/IJN.S238800

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© 2020 Zhao et al.

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Implantation procedure, X-ray and 3D reconstruction analysis of new bone. (A) Photographs showing the surgical implantation procedure (A1 and A2) of the CPH, and CPHI scaffolds in rabbit bone defects. (A3) shows the defect control covered by the connective tissue after 12 weeks. (B1–B6) New bone formation of CPH and CPHI groups after 4, 8, and 12 weeks. (C1–C9) Evaluation of in vivo bone formation: representative X-ray images showing the level of the regenerated bone tissue after 4–12 weeks. (D1–D9) 3D reconstruction images showed the different reparative effects of the CPH and CPHI scaffolds after 4–12 weeks. Red arrows: bone density, Red dotted circles: defect areas, Red arrow: density bone regeneration.