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. 2020 May 1;15:3039–3056. doi: 10.2147/IJN.S238800

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© 2020 Zhao et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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Histological staining assessment of the newly formed bone at 4–12 weeks post implantation of CPH and CPHI scaffolds in rabbit bone defects. (A) Staining with haematoxylin and eosin (H&E) demonstrates new bone formed in the CPH and CPHI scaffolds. (B) Masson’s trichrome shows matrix distribution (scale bar = 100 µm). (C) and (D) Show the quantitative data from (A) and (B), respectively. Data display the mean relative values calculated from three independent experiments (mean ± SD). * p < 0.05; ** p < 0.01; *** p < 0.001; * is the significance compared to defect control, ^# p < 0.05; is the significance compared to CPH group.

Abbreviations: NB, new bone; M, implanted material; HB, host bone; F, fibrous tissue.