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. 2020 May 1;15:3039–3056. doi: 10.2147/IJN.S238800

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© 2020 Zhao et al.

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Immunohistochemistry staining for (A) alkaline phosphatase (ALP), (C) type I collagen (COL1), (E) osteocalcin (OC), and (G) osteopontin (OPN) of bone defects at 4–12 weeks post implantation in rabbits. (B), (D), (F), and (H) Show the quantitative data from (A), (C), (E), and (G), respectively. Data display the mean relative values calculated from three independent experiments (mean ± SD). * p < 0.05; ** p < 0.01; * is the significance compared to defect control, ^# p < 0.05; is the significance compared to CPH group. Scale bar = 100 µm.

Abbreviations: NB, new bone; F, fibrous tissue.