Table 1.
Types of Micelles | Composition | Preparation Methods | Major Outcome | References |
---|---|---|---|---|
Normal micelles | MPEG-PCL | Solid dispersion method | Improved water solubility Inhibition of breast tumor growth and spontaneous pulmonary metastasis |
[51] |
EGFR-targeted micelles | PLGA-PEG GE11 peptides |
Emulsification solvent evaporation method | Increased intracellular uptake Prolonged circulation A reduction in primary tumor burden |
[58] |
FR-targeted micelles | Folate-PEG3000-PLA2000 mPEG2000-PLA2000 |
Thin film-hydration method | Increased intracellular uptake Sustained drug release Improved solubility Cancer targeting Enhanced anti-cancer activity |
[13] |
pH-sensitive micelles | TPGS-PAE | Solvent evaporation method | Low polydispersity High encapsulation efficiency Enhanced release in the acidic environment Improved pro-apoptotic and antiangiogenic activities |
[60] |
Redox-sensitive micelles | C16-SS-CS-mPEG | Dialysis method | Controlled drug release Enhanced antitumor and anti-inflammation efficacy |
[61] |