Table 2.

Analgesic Effect of Phenytoin versus Placebo on NRS Score After 30 Minutes

Population	Phenytoin		Placebo		Mean Difference
	Post Application NRS Score				Mean NRS Difference
	Mean	95% CI	Mean	95% CI	Mean	95% CI	P-value
All patients (N = 12)	4.3	3.5 to 5.1	5.2	4.4 to 6.0	0.9	0.4 to 1.4	0.003
Responders* (N = 6)	3.0	2.5 to 3.5	4.3	3.8 to 4.8	1.3	1.1 to 1.8	< 0.001
Non-responders (N = 6)	5.7	5.2 to 6.2	6.2	5.7 to 6.7	0.5	−0.2 to 1.2	0.2
	% Pain Reduction from Baseline				Mean % Difference
	Mean	95% CI	Mean	95% CI	Mean	95% CI	P-value
All patients (N = 12)	29	13 to 45	12	−2 to 26	17	6 to 28	0.006
Responders* (N = 6)	51	40 to 62	28	15 to 42	22	13 to 32	0.001
Non-responders (N = 6)	8;	−5 to 20	−4	−20 to 11	12	−12 to 36	0.3

Note: *Responder is defined as ≥2 points pain reduction on the NRS as well as ≥1 point difference between the phenytoin 10% cream and the placebo cream applied area in favour of phenytoin 10% cream.

Abbreviations: NRS, 11-point numerical rating scale, CI, confidence interval; N, number of patients.