Table 4.
Associations of maternal and neonatal 25OHD and ASD by presence or absence of intellectual disability in the Stockholm Youth Cohort. N of exposed ASD cases in each strata of analysis / odds ratio (95% confidence interval)
| Outcome | Total sample n = 766 | Nordic mothersa n = 573 |
|---|---|---|
| ASD | ||
| Maternal below median, neonatal below median | 131/1.75 (1.08, 2.86) | 57/1.94 (1.11, 3.41) |
| Maternal below median, neonatal above median | 60/1.48 (0.92, 2.40) | 51/1.78 (1.04, 3.06) |
| Maternal above median, neonatal below median | 51/1.17 (0.73, 1.89) | 46/1.04 (0.62, 1.75) |
| Maternal above median, neonatal above median | 98/Ref | 93/Ref |
| ASD without ID | ||
| Maternal below median, neonatal below median | 73/2.13 (1.24, 3.70) | 46/1.99 (1.09, 3.63) |
| Maternal below median, neonatal above median | 40/1.50 (0.86, 2.59) | 38/1.64 (0.91, 2.96) |
| Maternal above median, neonatal below median | 39/1.11 (0.65, 1.89) | 36/1.02 (0.57, 1.78) |
| Maternal above median, neonatal above median | 74/Ref | 72/Ref |
| ASD with ID | ||
| Maternal below median, neonatal below median | 58/1.24 (0.56, 2.72) | 11/2.03 (0.76, 5.40) |
| Maternal below median, neonatal above median | 20/1.46 (0.68, 3.08) | 13/2.40 (0.95, 6.05) |
| Maternal above median, neonatal below median | 12/1.20 (0.52, 2.65) | 10/0.83 (0.32, 2.11) |
| Maternal above median, neonatal above median | 24/Ref | 21/Ref |
Median sera 25OHD: 55.1 nmol/L; median neonatal 25OHD: 27.2 nmol/L
Estimates are derived from logistic regression models adjusted for year of birth, sample month, and maternal characteristics: psychiatric disorders, age, body mass index, smoking, nutritional supplement use, and region of origin
aAdjusted for all of above except for maternal region of origin