Table 4.
Freedom for Incident Adverse Events Categorized by Average Blood Pressure during Continuous Flow LVAD support. Patient average blood pressure was calculated from measures obtained at month 3 and onward.
| Freedom from Incident Event at 3 years | |||||
|---|---|---|---|---|---|
| Stroke | Renal Failure |
Confirmed Pump Thrombosis |
Infection | RV Failure | |
| INTERMACS Cohort | 82±0.4% | 85±0.4% | 95±0.3% | 36±0.6% | 87±0.4% |
| Mean Arterial Pressure Sample (n=8393 patients) | |||||
| Log rank p | 0.22 | <0.0001 | 0.025 | <0.0001 | 0.001 |
| MAP ≤75 (n=1505) | 81±1.5% | 80±1.4% | 94±0.9% | 28±1.7% | 82±1.5% |
| MAP 76-90 (n=4611) | 83±0.7% | 85±0.7% | 96±0.4% | 34±0.9% | 85±0.7% |
| MAP 91-100 (n=1744) | 83±1.1% | 86±1.1% | 96±0.7% | 35±1.6% | 87±1.1% |
| MAP >100 (n=533) | 78±2.5% | 82±1.9% | 94±1.5% | 41±2.8% | 84±2.6% |
| Doppler Opening Pressure Sample (n=10766) | |||||
| Log rank p | 0.016 | <0.001 | 0.031 | <0.0001 | <0.0001 |
| ≤80 mmHg (n=2840) | 80±1.2% | 83±1.1% | 95±0.7% | 35±1.3% | 81±1.2% |
| 81-95 mmHg (n=5890) | 84±0.6% | 88±0.6% | 96±0.4% | 40±0.9% | 84±0.7% |
| 96-104 mmHg (n=1400) | 82±1.3% | 86±1.2% | 96±0.3% | 39±1.7% | 84±1.3% |
| ≥105 mmHg (n=636) | 79±2.2% | 84±1.9% | 93±1.4% | 46±2.6% | 85±2.0% |
| Systolic Blood Pressure sample (n=10041) | |||||
| Log rank p | 0.001 | <0.0001 | 0.17 | <0.0001 | 0.17 |
| <90 mmHg (n=2537) | 84±1.1% | 82±1.0% | 97±0.6% | 31±1.3% | 88±1.0% |
| 90-107 mmHg (n=4680) | 84±0.7% | 86±0.6% | 96±0.4% | 34±0.9% | 86±0.7% |
| 108-119 mmHg (n=1980) | 80±1.2% | 85±1.1% | 95±0.7% | 37±1.4% | 86±1.1% |
| ≥120 mmHg (n=844) | 79±2.0% | 85±1.7% | 96±1.0% | 39±2.3% | 83±2.0% |