Table 7.
Freedom from Adverse Events Categorized by Average Blood Pressure during Axial Flow LVAD Support. Patient average blood pressure was calculated from measures obtained month 3 and onward after LVAD.
| Freedom from Incident Event at 3 years, Axial Flow Cohort | |||||
|---|---|---|---|---|---|
| Stroke | Renal Failure |
Confirmed Pump Thrombosis |
Infection | RV Failure | |
| All Axial Flow | 83±0.5% | 85±0.4% | 95±0.3% | 37±0.6% | 87±0.5% |
| Mean Arterial Pressure Sample (n=7046 patients) | |||||
| Log rank p | 0.40 | <0.001 | 0.005 | <0.0001 | 0.27 |
| MAP ≤75 mmHg (n=1176) | 84±1.6% | 77±1.4% | 94±1.0% | 29±1.8% | 86±1.5% |
| MAP 76-90 mmHg (n=3896) | 84±0.8% | 84±0.7% | 96±0.4% | 34±1.0% | 86±0.8% |
| MAP 91-100 mmHg (n=1496) | 84±1.2% | 86±1.2% | 96±0.7% | 36±1.7% | 88±1.1% |
| MAP >100 mmHg (n=478) | 79±2.6% | 87±2.0% | 95±1.5% | 42±2.9% | 85±2.6% |
| Doppler Opening Pressure Sample (n=8619) | |||||
| Log rank p | 0.019 | <0.0001 | 0.016 | 0.001 | 0.24 |
| ≤80 mmHg (n=2051) | 82±1.3% | 84±1.2% | 95±0.7% | 36±1.5% | 84±1.3% |
| 81-95 mmHg (n=4783) | 85±0.7% | 88±0.6% | 96±0.4% | 40±0.9% | 86±0.7% |
| 96-104 mmHg (n=1211) | 84±1.4% | 87±1.2% | 97±0.7% | 40±1.8% | 86±1.3% |
| ≥105 mmHg (n=572) | 79±2.3% | 84±2.0% | 94±1.4% | 43±2.7% | 86±2.0% |
| Systolic Blood Pressure sample (n=8577) | |||||
| Log rank p | 0.001 | <0.0001 | 0.63 | <0.0001 | 0.003 |
| <90 mmHg (n=2150) | 84±1.1% | 82±1.1% | 97±0.6% | 31±1.4% | 91±0.9% |
| 90-107 mmHg (n=3969) | 85±0.7% | 86±0.7% | 96±0.4% | 34±1.0% | 89±0.6% |
| 108-119 mmHg (n=1722) | 81±1.3% | 85±1.1% | 96±0.6% | 38±1.5% | 87±1.2% |
| ≥120 mmHg (n=736) | 80±2.1% | 85±1.8% | 96±1.0% | 38±2.4% | 85±2.0% |
INTERMACS= Interagency Registry of Mechanically Assisted Circulatory Support; LVAD= left ventricular assist device; RV= right ventricular