Skip to main content
. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: FASEB J. 2020 Mar 12;34(5):6229–6243. doi: 10.1096/fj.201903236R

Figure 7.

Figure 7.

siRNA knockdown of Tac1 abrogates the promotion of VEC proliferation and tube formation by inflamed TG neurons. (A) TG neurons derived from mice with DED were transfected with control non-target or Tac1 siRNA. Tac1 mRNA expression was reduced by 87% (n=4). (B) VEC proliferation was reduced when co-cultured with TG neurons transfected with Tac1 siRNA, compared with control siRNA (n=4). VEC proliferation (C, n=8) and tube formation (D, E, F n=5) were reduced when VEC were cultured in the conditioned media derived from DED TG neurons transfected with Tac1 siRNA, compared with those transfected with control siRNA. *p<0.05, **p<0.01.