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. 2020 Mar 29;34(5):6554–6569. doi: 10.1096/fj.202000240RR

Figure 1.

Figure 1

Design of experiment. Young adult female Sprague Dawley rats were randomly divided into one of four groups: age‐ and weight‐matched food‐restricted controls (FRC); task rats that were handled for 1 wk and then shaped for 6 wk, before going on to perform a HRHF task for 18 wk (HRHF‐Untreated); and task rats that performed the HRHF task for 18 wk before cessation of the task for 6 wk with simultaneous systemic treatment with a human immunoglobulin (HRHF‐Rest/IgG) or with an anti‐CCN2 antibody called FG‐3019 or pamrevlumab (HRHF‐Rest/FG‐3019, hereafter), before euthanasia. Additional animals were used for serum estradiol assays, as delineated in Figure S3